Marcaine 0.5% with 1:200,000 Epinephrine - 50/Box (99184)

• A long-acting local anesthetic containing 0.5% bupivacaine HCl and epinephrine 1:200,000

• It is manufactured by Septodont under the Cook-Waite brand for dental procedures in adults

• This anesthetic is used when a prolonged duration of pain control is desired, especially for procedures with significant postoperative pain

Uses

• Marcaine is used by licensed dental and oral surgery professionals for:

• Infiltration and nerve block injections in the maxillary and mandibular area

• Dental and oral surgical procedures, such as complex extractions, implant placement, periodontal surgery, and extensive crown or bridge preparations
  

Features

• Extended duration: 

• Provides significantly longer pain control than more common anesthetics like lidocaine and mepivacaine, often lasting up to 7 hours for soft tissue analgesia

• Fast onset: 

• Anesthesia typically begins within 2 to 10 minutes, allowing for timely and effective treatment

• Epinephrine content: 

• The inclusion of epinephrine acts as a vasoconstrictor, which limits systemic absorption and helps reduce bleeding at the injection site

• Allergen-free formulation: 

• Made with no methylparaben and 100% latex-free components to reduce the risk of allergic reactions in sensitive patients

• High safety standards:

•  Features a terminal sterilization process for the cartridges and includes a Mylar label on each glass cartridge to minimize the risk of injury from breakage

Side effects

Common side effects

• Nausea and vomiting

• Headache

• Dizziness

• Numbness, tingling, or pain at the injection site

• Fast, irregular, or pounding heartbeat

• Anxiety or restlessness 

Serious side effects

• Systemic toxicity: 

• High blood levels of bupivacaine can lead to serious central nervous system (CNS) and cardiovascular effects

• These can include blurred vision, ringing in the ears, tremors, convulsions, respiratory arrest, and heart arrhythmia or cardiac arrest

• Methemoglobinemia: 

• A rare but serious blood condition that can occur with local anesthetic use

• Symptoms include pale, gray, or blue-colored skin, headache, lightheadedness, and fatigue

• Prolonged numbness: 

• The extended duration of the anesthetic can cause inadvertent trauma to the tongue, lips, and oral mucosa

• Patients are advised not to eat or chew solid foods until sensation has fully returned

• Allergic reactions: 

• The product contains sodium metabisulfite and should not be used in patients with a sulfite sensitivity, which can cause anaphylaxis and other asthmatic reactions in susceptible individuals

Contraindications

• Patients with a known hypersensitivity to bupivacaine, other amide-type anesthetics, or any other component of the formulation

• Use in pediatric patients under 12 years of age is not recommended

• Intravenous regional anesthesia (Bier Block) and obstetrical paracervical block anesthesia